PDRN Serums: Why Salmon DNA Beats Vegan Alternatives for Glowy Skin

PDRN (polydeoxyribonucleotide) is a cult favorite in Korean skincare, especially for its glow-enhancing, plumping effects. Sourced from salmon DNA, PDRN contains natural building blocks (deoxyribonucleotides) that help boost skin renewal and elasticity by stimulating adenosine A2A receptors (Kim et al., 2016). 

Salmon PDRN vs. Vegan PDRN 
Vegan PDRN, typically synthesized through fermentation processes, mimics the nucleotide sequence but lacks the natural polynucleotide complexity of salmon-derived PDRN. A 2021 comparative study (Lee et al., 2021) suggests salmon PDRN shows superior effects in promoting visible skin hydration, elasticity, and overall glow due to its richer fragment profile. 

References: 

  • Kim H.J. et al. (2016), Ann Dermatol 

  • Lee Y.J. et al. (2021), Cosmetic Science Journal – “Comparative efficacy of natural vs synthetic PDRN in cosmetic formulations.” 

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